Generation of a homozygous GBA deletion human embryonic stem cell line
نویسندگان
چکیده
منابع مشابه
Generation of a Bag1 homozygous knockout mouse embryonic stem cell line using CRISPR/Cas9.
Bag1 transcribes a multifunctional protein that participates in many important biological processes such as cell apoptosis, proliferation, differentiation and embryo development. Despite numerous published studies, the role of Bag1 in the context of embryonic stem (ES) cells, has not been explored. To investigate the function of Bag1 in ES cells, we generated mutant Bag1-/- ES cells using the C...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2017
ISSN: 1873-5061
DOI: 10.1016/j.scr.2017.07.009